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Comparing Amylin Meds and GLP-1s Because amylin-based therapies may be better tolerated than GLP-1s, some pharmaceutical companies believe these drugs will provide an attractive alternative for patients with obesity, diabetes, or both conditions

Tirzepatide, the ingredient in Mounjaro, targets both GLP-1 and GIP receptors, which is a key structural and functional difference between the two medication families

Generally, candidates have a specific Body Mass Index (BMI), often 30 or greater, or 27 or greater with a weight-related condition like high blood pressure

What have you found in the research and in your clinical experience that these medications are doing outside of just the weight loss conversation

The scale might not move significantly, but how your clothes fit starts changing

The answer isnt as clear cut as you might imagine, suggests endocrinologist Caroline Messer, M.D